2025
The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation
Metabolic Brain Disease (2025)
Gladen-Kolarsky N., Neff C.J., Hack W., Brandes M.S., Wiedrick J., Meza-Romero R., Lockwood D.R., Quinn J.F., Offner H., Vandenbark A.A., Gray N.E.
2024
CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells
PLoS Biol. 2024;22. doi: 10.1371/journal.pbio.3002905
Pellegrino B., David K., Rabani S., Lampert B., Tran T., Doherty E., Piecychna M., Meza-Romero R., Leng L., Hershkovitz D., et al.
2023
Novel therapeutic for multiple sclerosis protects white matter function in EAE mouse model
Front. Mol. Med. 3:1237078. doi: 10.3389/fmmed.2023.1237078
Zerimech S., Nguyen H., Vandenbark A.A., Offner H., Baltan S.
2023
Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine
Front. Psychiatry 14:1259041. doi: 10.3389/fpsyt.2023.1259041
Loftis J.M., Ramani S., Firsick E.J., Hudson R., Le-Cook A., Murnane K.S., Vandenbark A., Shirley R.L.
2022
"Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct
Cellular Immunology, 2022:378, 104561
Vandenbark A.A., Meza-Romero R., Wiedrick J., Gerstner G., Seifert H., Kent G., Piechycna M., Benedek G., Bucala R., Offner H.
2019
A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury
Journal of Neuroinflammation, 16, 14 (2019)
Vandenbark A.A., Meza-Romero R., Benedek G., Offner H.
2014
RTL treatment improves neurological outcomes in the presence of tPA in experimental ischemic stroke
Translational Stroke Research, 2014, 5:612–617
2014
HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis
Journal of Immunology, 2014, 192, 4164–4173
2014
Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration
Acta Neuropathologica Communications, 2014, 2, 143–153
2013
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects
European Journal of Immunology, 2013, 43, 1309–1321
2013
A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance
Journal of Autoimmunity, 2013, 40C, 96:10
2013
Partial MHC/neuroantigen peptide constructs: a potential neuroimmune-based treatment for methamphetamine addiction
PLoS One, 2013;8:e56306
Loftis J.M., Wilhelm C.J., Vandenbark A.A., Huckans M.